Women's economic empowerment in the field of tourism entrepreneurship is considered a key strategy in achieving sustainable development and gender justice. This study was conducted with the aim of investigating the factors affecting the economic empowerment of women entrepreneurs in the tourism industry of Lorestan province. This study was applied in purpose and descriptive-analytical in data collection method (of a survey type), which was conducted using a quantitative approach and Structural Equation Modeling (SEM) method. The statistical population included all active women entrepreneurs in the tourism industry of Lorestan province, and 164 complete questionnaires were collected and analyzed using the available sampling method. The research tool was a researcher-made questionnaire whose validity was confirmed through content validity and its reliability with a Cronbach's alpha coefficient of 0.916. The findings of the study showed that the four main institutional factors (explaining 40.322% of the variance), social capital (6.905%), economic capital (6.47%), and cultural capital (5.278%) explain a total of 58.975% of the variance in women's economic empowerment. Among these factors, the institutional-structural factor was identified as the most important determinant, which included components such as obtaining business licenses, social and cultural norms, government laws, local community attitudes, and coordination with government institutions. The results obtained indicate that women's economic empowerment in Lorestan tourism is a multidimensional phenomenon that cannot be achieved only by providing economic capital, but improving the institutional context, strengthening social capital, and promoting cultural capital are necessary prerequisites and supplements for it.